Brown adipose tissue thermogenesis precedes food intake in genetically obese Zucker (fa/fa) rats

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Brown adipose tissue thermogenesis precedes food intake in genetically obese Zucker (fa/fa) rats.

In Sprague-Dawley rats, brown adipose tissue (BAT) thermogenesis occurs in an episodic ultradian manner (BAT on-periods) as part of the basic rest-activity cycle (BRAC). Eating occurs approximately 15min after the onset of BAT on-periods. Zucker obese (fa/fa) rats eat larger less frequent meals than control rats. In chronically instrumented conscious unrestrained Zucker obese rats we examined u...

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Brown adipose tissue thermogenesis in obese animals.

(Hales, J. R. S., eds.), pp. 169-173, Raven Press, New York Nedergaard, J., Alexson, S. & Cannon, B. (1980) Am. J . Physiol. 239, C208Z2 16 Nedergaard, J., Connolly, E., NBnberg, E. & Mohell, N. (1984) Biochem. Soc. Trans. 12, 393-396 Nedergaard, J., Connolly, E. & Cannon, B. (1986) in Brown Adipose Tissue (Trayhurn, P. & Nicholls, D. G., eds.), Edward Arnold, London, in the press Raasmaja, A.,...

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Reduced brown adipose tissue thermogenesis of obese rats after ovariectomy.

Brown adipose tissue (BAT) thermogenesis was assessed by measuring mitochondrial guanosine diphosphate (GDP) binding, cytochrome oxidase activity and oxygen consumption in ovariectomized (OVX) and sham-operated rats. The food intake and body weight of OVX rats increased more than those of controls and OVX rats became obese. Mitochondrial GDP binding, as an indicator of thermogenic activity, cyt...

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Thermogenesis in brown adipose tissue of genetically obese, diabetic (KKAY) mice.

Thermogenesis of brown adipose tissue (BAT) of genetically obese mice, KKAY mice, was examined by measuring the BAT mitochondrial guanosine diphosphate (GDP) binding as an index of thermogenesis and comparing it with that of normal C57BL mice. No great difference in GDP binding was observed in KKAY and C57BL mice fed a stock diet. However, when they were given a sucrose solution, the increase i...

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Development of fatty acid-synthetic capacity in interscapular brown adipose tissue during suckling in genetically obese Zucker rats.

The development of the lipogenic capacity in brown adipose tissue was studied in suckling lean (Fa/fa) and obese (fa/fa) Zucker pups aged from 7 to 22 days. In both lean and obese pups, activities of the two key lipogenic enzymes, fatty acid synthetase and acetyl-CoA carboxylase, and of citrate cleavage enzyme rose from the early to the late suckling period. Compared with lean pups, 7-day-old f...

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ژورنال

عنوان ژورنال: Physiology & Behavior

سال: 2013

ISSN: 0031-9384

DOI: 10.1016/j.physbeh.2013.05.021